5. The following image is of ASOanalysis performed at 90°C on afamily with Ty Sachs (M and F are theparents, C1, C2 and C3 are thechildren), and 2 unrelated controls.These parents had a normal child andthen had a child with Ty Sachs andthey want to know if their third childwill have it. The top ASO dotrepresents the Ty Sachs allele andthe bottom represents the normalallele.b. What is the status of the 3 children?c. What are the controls?TZNa. What is the status of the parents? (Have disease, are carriers, are normal?)d. The following panel is of a similar analysisdone, excpet the technician found that themachine had been set to the wrongtemperature for analysis. Is the temperaturethe machine set to higher or lower? Explainwhy.6. A murder victim is found in an advanced state ofdecomposition and cannot be identified. Policesuspect that the victim is one of 5 individualsreported missing by their parents. DNA typing(RFLP) is carried out against those 5 sets ofparents.According to loci 1 only, which couple could be theparents of the dead individual found?Who are the parents of the individual found(combine both data)?According to loci 2 only, which couple could be theparents of the dead individual found?MΤΖFNC1C1A B C D Ed d d d d d 59 59 xControl 1-Control 1Control 2Control 2A B C D E6 9 6 2 d 98989 X

Name: 5. The following image is of ASOanalysis performed at 90°C on afamily
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Description: 5. The following image is of ASOanalysis performed at 90°C on afamily with Ty Sachs (M and F are theparents, C1, C2 and C3 are thechildren), and 2 unrelated controls.These parents had a normal child andthen had a child with Ty Sachs andthey want to

Tay-Sachs disease is a rare genetic metabolic disease that primarily affects young children. It is…

Answered: 5. The following image is of ASO…

Human Anatomy & Physiology (11th Edition)

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Author:Elaine N. Marieb, Katja N. Hoehn

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Chapter1: The Human Body: An Orientation

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5. The following image is of ASO
analysis performed at 90°C on a
family with Ty Sachs (M and F are the
parents, C1, C2 and C3 are the
children), and 2 unrelated controls.
These parents had a normal child and
then had a child with Ty Sachs and
they want to know if their third child
will have it. The top ASO dot
represents the Ty Sachs allele and
the bottom represents the normal
allele.
b. What is the status of the 3 children?
c. What are the controls?
TZ
N
a. What is the status of the parents? (Have disease, are carriers, are normal?)
d. The following panel is of a similar analysis
done, excpet the technician found that the
machine had been set to the wrong
temperature for analysis. Is the temperature
the machine set to higher or lower? Explain
why.
6. A murder victim is found in an advanced state of
decomposition and cannot be identified. Police
suspect that the victim is one of 5 individuals
reported missing by their parents. DNA typing
(RFLP) is carried out against those 5 sets of
parents.
According to loci 1 only, which couple could be the
parents of the dead individual found?
Who are the parents of the individual found
(combine both data)?
According to loci 2 only, which couple could be the
parents of the dead individual found?
M
ΤΖ
F
N
C1
C1
A B C D E
d d d d d d 59 59 x
Control 1
-
Control 1
Control 2
Control 2
A B C D E
6 9 6 2 d 98989 X

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