5. Patients with palmoplantar keratoderma (PPK) have yellowish thickening of the skin on their hands and feet. Here is the pedigree of a family that has PPK. 2 Beneath the pedigree are two gels with results of PCR amplification of two STRS (short tandem repeats, similar to VNTRS). D12S3 is located near the keratin 1 gene, and D17S5 is located near the keratin 9 gene. There are 5 alleles of D12S3 (A-E) and 4 alleles of D1755 (A-D). -1 1-2 |l-1 I-2 |I-3, Keratin 1 D1283 A. B. C. D. E. In this family, do individuals with PPK likely have a mutation in keratin 1, keratin 9, or both? Explain, describing the data that 1 1-2 ||-1 |-2 I1-3 D17S5 Keratin 9 A. B. supports your conclusion. C. D. What follow-up experiments/data would you like to verify your conclusions? Explain.

5. Patients with palmoplantar keratoderma (PPK) have yellowish thickening of the skin on their hands and feet. Here is the pedigree of a family that has PPK. 2 Beneath the pedigree are two gels with results of PCR amplification of two STRS (short tandem repeats, similar to VNTRS). D12S3 is located near the keratin 1 gene, and D17S5 is located near the keratin 9 gene. There are 5 alleles of D12S3 (A-E) and 4 alleles of D1755 (A-D). -1 1-2 |l-1 I-2 |I-3, Keratin 1 D1283 A. B. C. D. E. In this family, do individuals with PPK likely have a mutation in keratin 1, keratin 9, or both? Explain, describing the data that 1 1-2 ||-1 |-2 I1-3 D17S5 Keratin 9 A. B. supports your conclusion. C. D. What follow-up experiments/data would you like to verify your conclusions? Explain.

Biology: The Unity and Diversity of Life (MindTap Course List)

15th Edition

ISBN:9781337408332

Author:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr

Publisher:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr

Chapter15: Studying And Manipulating Genomes

Section: Chapter Questions

Problem 15SQ: Match each term with the most suitable description. ______ DNA profile a. GMO with a foreign gene...

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