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- WaRetajarmecology Mcosolt Stream Which the following statements is/ are true regarding the illustrated drug? H,N -COOH 1. The nitrogen plays a role in the mechanism of action unlike chlorine atom. IL. The aromatic ring increases its chemical stability IL It is a prodrug IV.t binds to its target irreversibly V. A phenylalanine moiety can increase the entry into cancer cells1, OXIDATION: I. Saturated fats are more susceptible II. Degree of oxidation can be measured by acid value determination III. Can be avoided by adding a natural anti-oxidant, BHA CHOICES: I onlyII onlyIII onlyI and IIII and IIII and IIII, II, IIINone of the above 2. TRIGLYCERIDE: I. Formed through dehydration resulting in loss of water II. Formed through hydrolysis resulting in loss of water III. Formed from reaction of hydroxyl group of glycerol and carboxyl group of fatty acids CHOICES: I onlyII onlyIII onlyI and IIII and IIII and IIII, II, IIINone of the above8. The brick red color formed in a positive result of Benedict's test comes from A. the oxidation of copper ions B. the reduction of copper ion C. the reduction of carbonyl group D. the oxidation of carboxyl group E. the breakdown of glycosidic linkage 9. The following molecule is a но H Н-С—N — С H H H H-N-C -C-0-P-0-C -H H H H H A. triacylglycerol B. steroid hormone C. phospholipid D. o-6 fatty acid E. cholesterol 10. Which of the following statements about nucleic acid is INCORRECT? A. Coenzyme A is a protein, not nucleic acid B. NAD is an example of nucleic acid C. Adenine base is the same in ribonucleotide and deoxyribonucleotide D. Helix is an example of the secondary structure of nucleic acid E. Hydrogen bond can be found in DNA 11. The nucleoside consists of a D-deoxyribose and a cytosine base is called A. cytidine B. deoxycytidine C. deoxycytidylate D. deoxyribosylcytosine E. deoxyribosylcytidine
- Which of these heterocyclic drugs is likely to be the least soluble in water? Use the Fsp³ parameter to decide. OH Tramadol Chemical Formula: C16H25NO2 YOUR OW Pantoprazole Torasemide Chemical Formula: C16H15F2N3O4S Chemical Formula: C16H20N4O3S Temazepam -OH Chemical Formula: C16H13CIN₂O2 Tioconazole Chemical Formula: C16H13C3N₂OS A. Tramadol B. Pantoprazole C. Torasemide D. Temazepam E. Toconazole3. The compound 5-hydroxymethyl furfural forms while heating or cooking sugar-containing foods. HO HO НО ...OH OH OH 5 hydroxymethyl furfural a. Draw arrow-pushing mechanism for the dehydration of fructose under acidic conditions (use H-A). b. What is the driving force for this reaction?6. When a concentrated alkali solution acts on the purine cycle, it breaks down: A. Ester group B. Imidazole nucleus C. Dioxopyrimidine nucleus D. Lactone cycle 7. According to the Pharmacopoeia, sodium thiopental is quantitatively determined by the following methods: A. Acidimetry B. Alkaimetry C. Gravimetry D. HPLC E. UV spectroscopy 8. When determining the content of free alkali in sodium salts of barbiturates, an indicator is used: A. Methyl orange B. Methyl red C. Timolphthalein D. Phenolphthalein 9. NH-acidic properties are shown by: A. Sulfacyl sodium B. Sodium barbital C. Theobromine D. Hexamidine (primidone) 10. Derivatives of pyrimidine-2,4-dione are derivatives: A. Uracil B. Uretane C. Barbituric acid D. Malonic acid 11. The cerimetric method can be used for quantitative analysis: A. Nicotinic acid B. Atropine sulfate C. Gomatropin hydrobromide D. Nicotinic acid diethylamide E. Nifedipin
- For 4-aminosalycilic acid please pick only the second choice phase 2 metabolite per handle present in the drug: OH H,N 4-Aminosalicylic acid OH إختر واحدة أو أكث OH OH NH, HN HO. OH HN HN он HO HO он HQ HO. HO. HN6. Treatment of cholesterol with mCPBA results in formation of a single epoxide A, with the stereochemistry drawn. Why isn't the isomeric epoxide B formed to any extent? H. H H HO HO A B14. The table below shows the percentage of Thymine (T) A C search 15% 30% 50% T 20% 60% O G C m Based on the information in the table, what is the percentage of Guanine (G) in the sample? Remember that the percentages must add up to 100%. O 14 15 16 17 18 19 *REQUIRED
- 4. Comment on the following: a. Whereas D-glucose is virtually unaffected by heating in dilute aqueous acid (apart from undergoing mutarotation), D-idose form the anhydrosugar X. Explain the different behaviour of the sugars. он OH HQ, OH но., OH HO.. H+ HO HO *CH¿OH но "CH,OH gluco se idoseNaturally alkaloids include: * O Bethanechol O Pilocarpine O Option 3 O Adrenaline3. Name the following oxidation/reduction product for the given monosaccharide. (2 pts each) COOH Сно H- OH но H- но -- но -- -OH H- -OH OH ČH2OH COOH а. b. COOH CHO H- -O- но -H но -H но но -H но -H H- -OH H -HO- COOH COOH C. d. COOH CH2OH H- -O- -OH -O- но H- Но -H -OH -OH H OH ČOOH ČH2OH е. f.