LABORATORY REPORT
Activity:
Homeostatic Imbalances of Thyroid Function
Name:
Theres Castle
Instructor:
Virgil Stoia
Date:
10.20.2014
Predictions
TSH levels in patients with primary hypothyroidism are high Thyroxine (T4) levels in patients with primary hypothyroidism are low TSH levels in patients with secondary hypothyroidism are low Thyroxine (T4) levels in patients with secondary hypothyroidism are low TSH levels in patients with hyperthyroidism are low Thyroxine (T4) levels in patients with hyperthyroidism are high Materials and Methods
1. Name the Dependent Variable. blood levels of TSH and thyroxine and accumulation of radioactive iodine in thyroid
2. Name the Independent Variable.
thyroid
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3. State how hypothyroidism affects each of the following and describe the mechanism by which this change occurs.
a. body temperature
Laboratory Report/ Theres Castle/ Homeostatic Imbalances of Thyroid Function/ Virgil Stoia/ 10.20.2014/ Page [2] of [3]
Thyroids control the blood vessels. The hypothyroidism enhanced the blood vessels. Thus leads to heat loss and the person will freeze.
b. heart rate
With hypothyroidism the thyroid does not produce enough T3 and T4 and this slows down the metabolism. This causes the heart to beat slower.
4. State how hyperthyroidism affects each of the following and describe the mechanism by which this change occurs.
a. body temperature
Thyroids control the blood vessels. The hyperthyroidism reduced the blood vessels. Thus leads to increased heat.
b. heart rate
With hypothyroidism the thyroid produces enough T3 and T4 and this fastens up the metabolism. This causes the heart to beat faster.
5. Restate your predictions that were correct and give the data from your experiment that supports them. Restate your predictions that were not correct and correct them, giving the data from your experiment that supports the corrections.
Correct Predictions: TSH levels in patients with primary hypothyroidism are high Thyroxine (T4) levels in patients with primary hypothyroidism
are
Hypothyroidism can affect the body temperature because it slows down the metabolism. This causes the energy produced to be less. With that
Hyperthyroidism also increases the basal metabolic rate, heat production and oxygen consumption (calorigenic action) of many tissues. Body temperature increases slightly and the patient experiences intolerance to heat. Flushing and sweating are just compensatory
The thyroid is a butterfly-shaped gland. You would find it located in the lower neck, right below the Adam’s apple. The location is the same in both men and women. What the thyroid does is create and store thyroid hormone. It then releases the hormone in appropriate amounts to keep the body’s metabolism functioning at a normal level. If there is too much thyroid hormone, this is known as hyperthyroidism. In hyperthyroidism, the body’s metabolism increases. This condition can cause high blood pressure, high heart rate, nervousness, palpitations, and severe weight loss. Too little thyroid hormone, on the other hand, can cause tiredness, depression, memory loss, dry skin, brittle hair, and weight gain—among many other symptoms.
Thyrotoxicosis is a clinical condition caused by excess circulating serum thyroxine (T4), triiodothyronine (T3), or both with suppression of thyroid-stimulating hormone (TSH). A negative feedback loop involving the hypothalamus, pituitary, and thyroid gland regulates the production and release of thyroid hormones. (Fig. 1) The hypothalamus releases thyroid-releasing hormone (TRH), stimulating the pituitary gland to release TSH, in turn stimulating the thyroid gland to release T4 and T3. Enhanced production of T4 and T3
Starting during prenatal development and continuing throughout life, thyroid hormones pay an important role in the cardiovascular system, the relationship in which has been seen to change in the case of thyroid dysfunction. The relationship between the heart and the thyroid has been demonstrated through a series of experimental and clinical studies and the results determined that in the case of hypothyroidism parameters such as blood volume and heart rate have been seen to decrease from 100% and 72-84bpm to 84.5 % and 60-80bpm respectively. The regular measurements of both the patients cardiac output and systemic vascular resistance have also been seen to change, shifting from 4.0-6.0 L/min and 1500-1700 dyn·sec/cm-5 to <4.5 L/min and 2100-2700
Describe the diagnosis for patient 3, who was also pregnant at the time of this assay. ***
The thyroid gland is found in the front of the neck and produces two main hormones. The hormones are called thuroxine (T4) and Triiodothyronine (T3). Together these hormones regulate the body’s metabolism by increasing energy use in cells, regulate growth and development, help to maintain body temperature and aid in oxygen consumption. These two hormones are regulated by hormones produced by the hypothalamus and pituitary gland. The hypothalamus senses changes in body’s metabolic rate and releases a hormone known as thyropin-releasing hormone (TRH). This hormone then flows through connecting vessels to the pituitary gland which signals it to release another hormone. This hormone is known as thyroid-stimulating hormone (TSH). TSH then makes
Aliza Young, a 25 year old female, was admitted to the hospital with complaints of rapid heart rate and palpitations. She states that her “heart has been jumping out of her chest”. She has been feeling more anxious and irritable as well. Upon assessment, Ms. Young’s skin appears flushed, moist, and warm. Ms. Young complains of feeling “overheated” and has been sweating profusely. She feels weak, has experienced an unusual amount of weight loss, and abnormal menstruation. Both the nurse and physician have suspicions of hyperthyroidism. Patient has no family history of thyroid disease. After lab results were received, the TSH
The 19th and 20th century brought great medical understanding to the thyroid gland. The thyroid was once though to lubricate the larynx; but during this time doctors began to understand the importance of the thyroid (Hamdy). According to the American thyroid association, Thomas Warton named the thyroid in 1656; due to a resemblance the gland had with a Greek shield. It wasn’t until 1850 the first case of hypothyroidism was finally described. Hypothyroidism is a condition in which the thyroid gland production of the thyroid hormone is abnormally low. The purpose of the thyroid hormone, which is secreted by the thyroid, is to maintain the metabolism throughout the body.
Usually, if a conversion in thyroidism occurs, it is the opposite of what’s occurring here: hyperthyroidism converts to hypothyroidism. In all three cases, the patients are middle aged, female, Asian, and all presented with common symptoms of primary clinical hypothyroidism. The first patient was 36 years old, and had symptoms of constipation, cold intolerance, polymenorrhagia, and weight gain over the course of three months. The second patient was 46 years old, and also had weight gain, as well as an increased desire to sleep. The third patient, at 43 years old and obese, felt lethargic, and had TSH levels higher than normal just like the other two. All three patients were easily fatigued, and were on Thyroxine hormone
Hypothyroidism happens when there is underproduction of the hormone thyroxin. The thyroid gland does not produce enough for what the body needs.
Hypothyroidism is defined as failure of the thyroid gland to produce sufficient thyroid hormone to meet the metabolic demands of the body.1 If left untreated it can contribute to dyslipidemia, hypertension, cognitive impairment, infertility, and neuromuscular dysfunction. One in 200 persons in the United States has hypothyroidism based on the data from National Health and Nutrition Examination Survey (NHANES III).1 The prevalence increases with age, and is higher in females than in males.1
The diagnosis of primary hypothyroidism is made by measurement of increased levels of TSH (thyroid stimulating hormone) and decreased levels of TH (thyroid hormone including total T, and both total and free T4)(McCance & Huether, 2014, p. 729). Thyroid disorders are detected by testing TSH, T4, and T3 levels in the blood. A decrease of thyroid hormone causes the pituitary gland to produce more TSH, which increase levels in the bloodstream in an attempt to encourage thyroid hormone production. This rise
The thyroid gland, which is located in your neck, produces key hormones in response to signals sent by your brain. These hormones work to increase or decrease your metabolic rate. When the thyroid gland is overactive, it is referred to as hyperthyroidism. More hormone is secreted than usual, which boosts your metabolic rate. This can cause heavy sweating, weight loss, heart palpitations, dry eyes, tremors and nervousness. Some people might also have difficulty breathing or swallowing. Treatments may include medication, radioactive iodine and in advanced cases, surgery might be recommended. The combination of diabetes and hyperthyroidism can worsen diabetes symptoms and lead to further complications. It is important to seek treatment
During the review of this scenario it was concluded based on laboratory test that were ran that the nurse was experiencing hyperthyroidism. The nurse came in due to abnormal symptoms that she was experiencing, symptoms which are often associated with thyroid problems. This lead to the healthcare providers running test to check her thyroid. Hyperthyroidism is when a person’s thyroid gland produces an excess amount of thyroid hormone than is necessary for the human’s body. Since the hormone is so prevalent in the body and is in control of the bodies energy, if there is a deficiency or surplus of thyroid hormone it will vastly alter the way the body works. When checking for hypothyroidism or hyperthyroidism it is often know to run a serum T4 and serum T3 test. The T4 test is a test that is ran to check the amount of thyroxine that is present in the person’s blood. The T4 levels have a normal range of 4.6 to 12 ug/dL. The nurse test results showed that her T4 was 15.6 ug/dL which is above the normal range and a sign of hyperthyroidism. The next test ran was a T3 serum test, this test measures the amount of triiodothyronine in the blood. The serum T3 levels have a normal range of 80